Black seeds are also known as black cumin or kalonji. They are derived from Nigella, a small plant with pale purple, blue, or white flowers that grows in Eastern Europe, Western Asia, and the Middle East. For thousands of years, people have used the tiny black seeds of the fruits as a natural remedy. The seeds, like cumin or oregano, can be used to flavor curries, pickles, and bread. Black seed oil contains thymoquinone, an antioxidant and anti-inflammatory compound that may also have tumor-reducing properties. To benefit the skin, people can take black seed oil capsules or apply it topically.