Benzoyl Peroxide Acne Treatment. Maximum strength effectiveness. Less irritation, won't dry out skin. Touch on acne, easy on your skin. Vanishing Formula - Absorbs quickly, works invisibly. Break the breakout cycle. Some medicated spot treatments contain high levels of benzoyl peroxide that can irritate skin, causing redness and dryness which can make acne worse. Neutrogena On-the-Spot Acne Treatment has been clinically proven to provide maximum strength effectiveness in fighting acne, while being gentle to the skin. Maximum strength effectiveness with less irritation, won't dry out skin. Neutrogena On-the-Spot Acne Treatment contains just 2.5% benzoyl peroxide, yet has been clinically proven to provide the same maximum level of effectiveness as a 10% formula, and with 70% less irritation overall. This fast working formula contains a special blend of ingredients to enhance the benzoyl peroxide's penetration.