ACNESTAR 0.05% W/W CREAM
COMPOSITION:Acnesol contais Tretinoin B.P 0.05% w/w as the active ingredient.
PHARMACOLOGY:Tretinoin
stimulates mitotic activity and increased turnover of follicular
epithelial cells causing extrusion of comedos. It also reduces
hperkeratinization that leads to microcomedo formation which is the
initial lesion in acne. In dermis blood vessel, vasodilation and
angiogenesis and increased papillary dermal collagen synthesis lead to
lessening of fine and course wrinkling smoother texture decrease in
hyperpigmentation.
PHARMACOKINETICS:Tretinoin is highly bound to
plasma roteins and undergoes metabolism in the liver. It’s excreted in
the bile and urine.
INDICATION:Acnesol is used for the treatment of the following
AcnePhotodamaged
skinHyperpigmentationADVERSE EFFECTSTretinoin is a skin irritant and
may cause peeling similar to that of sunburn. Sensitive inviduals may
experience oedema, buscemia and crusting of the skin.
DIRECTIONS:–    Apply gently on the affected areas 1-2 times a day or as directed by a physician.
CONTRAINDICATIONS:Tretinoin
is teratogenic and is contraindicated in pregnancy, breastfeeding
mothers, on eczematous sunburn or branded skin.Do not apply it with
other topical treatment e.g. skin moisturizers
DRUG INTERACTION:Interacts with Tetracyclines and Carbamazepine
PRESENTATION:Available in 25g collapsible Aluminium tubes packed in unit boxes.

STORAGE:Do
not store above 30°C. Store in a dry place. Keep tightly closed.
Protect from direct sunlight. Keep all medicines out of reach of
children.