Antifungal Creams

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What are antifungal medicines and how do they work?

There are several types of antifungal medicines. They come as creams, sprays, solutions, tablets designed to go into the vagina (pessaries), shampoos, medicines to take by mouth, and injections. Most work by damaging the cell wall of the fungus, which causes the fungal cell to die.

Antifungal creams, liquids or sprays (also called topical antifungals)

These are used to treat fungal infections of the skin, scalp and nails. They include clotrimazole, econazole, ketoconazole, miconazole, tioconazole, terbinafine, and amorolfine. They come in various different brand names.

Sometimes an antifungal cream is combined with other creams when two actions are required. For example, an antifungal cream is often combined with a mild steroid cream, such as hydrocortisone, to treat certain rashes. The antifungal cream clears the infection, and the mild steroid cream reduces the inflammation caused by the infection.

There are also separate leaflets in this series that deal with Candidal Skin Infection (Yeast Infection), Fungal Scalp Infection (Scalp Ringworm) and Fungal Nail Infections (Tinea Unguium).

Antifungal shampoo

A shampoo which contains ketoconazole is sometimes used to help treat scalp fungal infections and certain skin conditions.

Antifungal pessaries

Pessaries are tablets which are designed to be put into the vagina. Some antifungal medicines are used as pessaries to treat vaginal thrush, particularly clotrimazole, econazole, miconazole, and fenticonazole

Antifungal medicines taken by mouth

There are various types. For example:

Miconazole is available as an oral gel, and nystatin as a liquid. They are applied to the mouth. They are used to treat thrush (candidal infection) of the mouth and throat.

Terbinafine, itraconazole, fluconazole, posaconazole, and voriconazole are available as tablets, which are absorbed into the body. They are used to treat various fungal infections. The one chosen depends on what type of infection you have. For example:

Terbinafine is commonly used to treat nail infections which are usually caused by a tinea type of fungus. Fluconazole is commonly used to treat vaginal thrush, as an alternative to using antifungal cream. It is also used to treat and prevent certain fungal infections within the body. There are also separate leaflets in this series dealing with athlete's foot, ringworm and fungal groin infection.

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